Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review.

Brück, K; Jager, KJ; Dounousi, E; Kainz, A; Nitsch, D; Ärnlöv, J; Rothenbacher, D; Browne, G; Capuano, V; Ferraro, PM; Ferrieres, J; Gambaro, G; Guessous, I; Hallan, S; Kastarinen, M; Navis, G; Gonzalez, AO; Palmieri, L; Romundstad, S; Spoto, B; Stengel, B; Tomson, C; Tripepi, G; Völzke, H; Wiȩcek, A; Gansevoort, R; Schöttker, B; Wanner, C; Vinhas, J; Zoccali, C; Van Biesen, W; Stel, VS; European CKD Burden Consortium, . (incd. Fletcher, A. ), ; (2015) Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review. Nephrology, dialysis, transplantation, 30 Suppl 4. iv6-iv16. ISSN 0931-0509 DOI:

[img] Text - Published Version
License: Creative Commons Attribution Non-commercial

Download (273kB)


Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR) <60 mL/min/1.73 m(2) in 92% of studies. Urinary markers of CKD were assessed in 60% of the studies. CKD prevalence was reported by sex and age strata in 54 and 50% of the studies, respectively. In publications with a primary objective of reporting CKD prevalence, 39% reported a 95% confidence interval. The findings from this systematic review showed considerable variation in methods for sampling the general population and assessment of kidney function across studies reporting CKD prevalence. These results are utilized to provide recommendations to help optimize both the design and the reporting of future CKD prevalence studies, which will enhance comparability of study results.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: EHR Research Group
PubMed ID: 26209739
Web of Science ID: 359781800002


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item