The effect of BCG on iron metabolism in the early neonatal period: A controlled trial in Gambian neonates.


Prentice, S; Jallow, MW; Prentice, AM; MRC-International Nutrition Group, ; (2015) The effect of BCG on iron metabolism in the early neonatal period: A controlled trial in Gambian neonates. Vaccine, 33 (26). pp. 2963-7. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.04.087

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Abstract

: Bacillus Calmette-Guerin (BCG) vaccination has been reported to protect neonates from non-tuberculous pathogens, but no biological mechanism to explain such effects is known. We hypothesised that BCG produces broad-spectrum anti-microbial protection via a hepcidin-mediated hypoferraemia, limiting iron availability for pathogens. To test this we conducted a trial in 120 Gambian neonates comparing iron status in the first 5-days of life after allocation to: (1) All routine vaccinations at birth (BCG/Oral Polio Vaccine (OPV)/Hepatitis B Vaccine (HBV)); (2) BCG delayed until after the study period (at day 5); and (3) All routine vaccinations delayed until after the study period. Vaccine regime at birth did not significantly impact on any measured parameter of iron metabolism. However, the ability to detect an effect of BCG on iron metabolism may have been limited by short follow-up time and high activation of the inflammatory-iron axis in the study population.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 25959747
Web of Science ID: 357138700002
URI: http://researchonline.lshtm.ac.uk/id/eprint/2248369

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