Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity.


Campino, S; Bagot, S; Bergman, ML; Almeida, P; Sepúlveda, N; Pied, S; Penha-Gonçalves, C; Holmberg, D; Cazenave, PA; (2005) Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity. Genes and immunity, 6 (5). pp. 416-21. ISSN 1466-4879 DOI: https://doi.org/10.1038/sj.gene.6364219

Full text not available from this repository.

Abstract

Unprecedented cure after infection with the lethal Plasmodium berghei ANKA was observed in an F2 progeny generated by intercrossing the wild-derived WLA and the laboratory C57BL/6 mouse strains. Resistant mice were able to clear parasitaemia and establish immunity. The observed resistance was disclosed as a combinatorial effect of genetic factors derived from the two parental strains. Genetic mapping of survival time showed that the WLA allele at a locus on chromosome 1 (colocalizing with Berghei resistance 1 (Berr1), a locus associated with resistance to experimental cerebral malaria) increases the probability to resist early death. Also, the C57Bl/6 allele at a novel locus on chromosome 9 (Berr3) confers overall resistance to this lethal Plasmodium infection. This report underlines the value of using wild-derived mouse strains to identify novel genetic factors in the aetiology of disease phenotypes, and provides a unique model for studying parasite clearance and immunity associated with malaria.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 15973462
Web of Science ID: 230882000005
URI: http://researchonline.lshtm.ac.uk/id/eprint/2234

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
281Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item