An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys.


Cano, J; Moraga, P; Nikolay, B; Rebollo, MP; Okorie, PN; Davies, E; Njenga, SM; Bockarie, MJ; Brooker, SJ; (2015) An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of the Royal Society of Tropical Medicine and Hygiene, 109 (8). pp. 529-31. ISSN 0035-9203 DOI: 10.1093/trstmh/trv048

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Abstract

BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.<br/> METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.<br/> RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 26101292
Web of Science ID: 359622700007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2220533

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