Sequential chemo-immunotherapy of experimental visceral leishmaniasis using single low dose liposomal amphotericin B and a novel DNA vaccine candidate.


Seifert, K; Juhls, C; Salguero, FJ; Croft, SL; (2015) Sequential chemo-immunotherapy of experimental visceral leishmaniasis using single low dose liposomal amphotericin B and a novel DNA vaccine candidate. Antimicrobial agents and chemotherapy, 59 (9). pp. 5819-23. ISSN 0066-4804 DOI: 10.1128/AAC.00273-15

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Abstract

: Combination therapies for leishmaniasis, including drugs and immunomodulators, are one approach to shorten treatment courses and to improve the treatment of complex manifestations of the disease. We evaluated a novel T-cell-epitope-enriched DNA vaccine candidate (LEISHDNAVAX) as host-directed immunotherapy in combination with a standard antileishmanial drug in experimental visceral leishmaniasis. Here we show that the DNA vaccine candidate can boost the efficacy of a single suboptimal dose of liposomal amphotericin B in C57BL/6 mice.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Neglected Tropical Diseases Network
Vaccine Centre
PubMed ID: 26055371
Web of Science ID: 364343900089
URI: http://researchonline.lshtm.ac.uk/id/eprint/2212792

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