Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.


Yardley, V; Gamarro, F; Croft, SL; (2010) Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. Antimicrobial agents and chemotherapy, 54 (12). pp. 5356-8. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00985-10

Full text not available from this repository. (Request a copy)

Abstract

The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC(50)s) between 0.1 and 4.0 ?M for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED(50)) values of 1.2 to 3.5 mg/kg for 5 days. Tafenoquine was less active against intracellular Trypanosoma cruzi amastigotes, with an IC(50) of 21.9 ?M.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 20837750
Web of Science ID: 284158000055
URI: http://researchonline.lshtm.ac.uk/id/eprint/2205

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
279Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item