Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands.


Marang-van de Mheen, PJ; ten Asbroek, AH; Bonneux, L; Bonsel, GJ; Klazinga, NS; (2002) Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands. European heart journal, 23 (24). pp. 1922-30. ISSN 0195-668X DOI: https://doi.org/10.1053/euhj.2002.3281

Full text not available from this repository.

Abstract

AIMS: To estimate the cost-effectiveness of the current screening programme on Familial Hypercholesterolaemia (FH) in relatives of diagnosed FH-patients in The Netherlands. METHODS AND RESULTS: Data from 2229 screened FH-relatives, including age, sex, risk factor status and screening outcome, were combined with the Framingham risk function and national disease-specific cost data to arrive at a model-based comparison of survival and costs, with and without the screening programme. Cost-effectiveness ratios were computed for various treatment strategies, with no screening as reference. Costs per life year gained varied between 25.5- and 32-thousand Euros, depending upon the precise treatment strategy after a positive screen. The costs for screening (tracing the FH-positive individuals) were much lower than the follow-up costs (treatment), of which 80% were costs for statins. Consequently, the costs per life year gained of alternative screening programmes are about the same. CONCLUSION: The cost-effectiveness ratio of FH screening is within the range requiring explicit political consideration in The Netherlands. As the costs of statin treatment are the single most important determinant of costs, policy decisions reduce to decisions on the acceptability of statin treatment for this risk group. Pending major changes in statin price, clear guidelines should be developed on how screen positive individuals should be treated, since not all of them have an elevated cholesterol level.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 12473254
Web of Science ID: 179811600009
URI: http://researchonline.lshtm.ac.uk/id/eprint/2176

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
273Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item