Review of Mass Drug Administration for Malaria and Its Operational Challenges.


Newby, G; Hwang, J; Koita, K; Chen, I; Greenwood, B; von Seidlein, L; Shanks, GD; Slutsker, LM; Kachur, SP; Wegbreit, J; Ippolito, MM; Poirot, E; Gosling, R; (2015) Review of Mass Drug Administration for Malaria and Its Operational Challenges. The American journal of tropical medicine and hygiene. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0254

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Abstract

Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility, and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in aspecific settings.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 26013371
Web of Science ID: 357764300023
URI: http://researchonline.lshtm.ac.uk/id/eprint/2173754

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