Uniting mathematics and biology for control of visceral leishmaniasis.


Rock, KS; le Rutte, EA; de Vlas, SJ; Adams, ER; Medley, GF; Hollingsworth, TD; (2015) Uniting mathematics and biology for control of visceral leishmaniasis. Trends in parasitology. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2015.03.007

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Abstract

The neglected tropical disease (NTD) visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017 or earlier. To date there is a surprising scarcity of mathematical models capable of capturing VL disease dynamics, which are widely considered central to planning and assessing the efficacy of interventions. The few models that have been developed are examined, highlighting the necessity for better data to parameterise and fit these and future models. In particular, the characterisation and infectiousness of the different disease stages will be crucial to elimination. Modelling can then assist in establishing whether, when, and how the WHO VL elimination targets can be met.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Centre for the Mathematical Modelling of Infectious Diseases
Leishmaniasis Group
Neglected Tropical Diseases Network
Social and Mathematical Epidemiology (SaME)
SaME Modelling & Economics
PubMed ID: 25913079
Web of Science ID: 356636500006
URI: http://researchonline.lshtm.ac.uk/id/eprint/2162885

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