Quality of the Antibiotics-Amoxicillin and Co-Trimoxazole from Ghana, Nigeria, and the United Kingdom.


Fadeyi, I; Lalani, M; Mailk, N; Van Wyk, A; Kaur, H; (2015) Quality of the Antibiotics-Amoxicillin and Co-Trimoxazole from Ghana, Nigeria, and the United Kingdom. The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 87-94. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.14-0539

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Abstract

: Little is known about the quality of antibiotics despite being in high demand globally. Thirty five samples (27 brands) of the antibiotics amoxicillin (N = 20; 16 brands) and co-trimoxazole (N = 15; 11 brands), manufactured in six countries (China, Ghana, India, Ireland, Nigeria, and United Kingdom), were purchased in Ghana, Nigeria, and the United Kingdom. Their quality was assessed using German Pharma Health Fund (GPHF) MiniLab® as the screening tool-two capsules of amoxicillin (10%) and two tablets of co-trimoxazole (20%) failed the thin-layer chromatography (TLC) test. Definitive drug quality was measured using high-performance liquid chromatography-photodiode array detection (HPLC-PDA) for content of the stated active pharmaceutical ingredients (APIs) and bioavailability was determined with in vitro dissolution testing. All the samples of amoxicillin complied with U.S. Pharmacopeia (USP) tolerance limits, but 60% tablets of co-trimoxazole (purchased in Ghana and Nigeria) did not. There was disparity in the results obtained for co-trimoxazole and amoxicillin samples using the MiniLab® TLC tests. This highlights the need to invest in techniques such as HPLC-PDA and dissolution testing alongside the screening tests for assessing drug quality.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 25897067
Web of Science ID: 355785600012
URI: http://researchonline.lshtm.ac.uk/id/eprint/2160107

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