The complex evolution of antibiotic resistance in Mycobacterium tuberculosis.


Fonseca, JD; Knight, GM; McHugh, TD; (2015) The complex evolution of antibiotic resistance in Mycobacterium tuberculosis. International journal of infectious diseases , 32. pp. 94-100. ISSN 1201-9712 DOI: 10.1016/j.ijid.2015.01.014

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Abstract

Multidrug-resistant and extensively drug-resistant tuberculosis (TB) represent a major threat to the control of the disease worldwide. The mechanisms and pathways that result in the emergence and subsequent fixation of resistant strains of Mycobacterium tuberculosis are not fully understood and recent studies suggest that they are much more complex than initially thought. In this review, we highlight the exciting new areas of research within TB resistance that are beginning to fill these gaps in our understanding, whilst also raising new questions and providing future directions.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 25809763
Web of Science ID: 352401500016
URI: http://researchonline.lshtm.ac.uk/id/eprint/2137900

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