Trachoma: an update on prevention, diagnosis, and treatment.


Bhosai, SJ; Bailey, RL; Gaynor, BD; Lietman, TM; (2012) Trachoma: an update on prevention, diagnosis, and treatment. Current opinion in ophthalmology. ISSN 1040-8738 DOI: https://doi.org/10.1097/ICU.0b013e32835438fc

Full text not available from this repository.

Abstract

: PURPOSE OF REVIEW: To review recent clinical and epidemiological studies regarding the prevention, diagnosis, and treatment of trachoma. RECENT FINDINGS: Newer studies propose novel diagnostic tests that appear sensitive for the detection of ocular chlamydial infection. For example, recent studies with ribosomal RNA-based nucleic acid amplification tests (NAATs) have demonstrated improved sensitivities compared to DNA-based NAATs; and the progression of scarring has now been characterized with confocal microscopy. Immunologic studies have further explored the etiology of clinical sequelae, suggesting that chronic inflammation can lead to progressive scarring even in the absence of Chlamydia. Mass oral azithromycin distributions remain a mainstay of treatment; studies have assessed the appropriate frequency and duration of treatment programs. Current studies have also explored ancillary effects of azithromycin distribution on mortality and bacterial infections. SUMMARY: Trachoma programs have had remarkable success at reducing chlamydial infection and clinical signs of trachoma. Recent work suggests improved methods to monitor infection and scarring, and better ways to distribute treatment. Whereas studies continue to demonstrate reduction in infection in hyperendemic areas, more work is necessary to achieve elimination of this blinding disease.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 22569465
Web of Science ID: 307945300010
URI: http://researchonline.lshtm.ac.uk/id/eprint/21143

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
293Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item