Modelling cerebrovascular reactivity: a novel near-infrared biomarker of cerebral autoregulation?


Highton, D; Panovska-Griffiths, J; Ghosh, A; Tachtsidis, I; Banaji, M; Elwell, C; Smith, M; (2013) Modelling cerebrovascular reactivity: a novel near-infrared biomarker of cerebral autoregulation? Advances in experimental medicine and biology, 765. pp. 87-93. ISSN 0065-2598 DOI: https://doi.org/10.1007/978-1-4614-4989-8_13

[img] Text - Published Version
License:

Download (502kB)

Abstract

Understanding changes in cerebral oxygenation, haemodynamics and metabolism holds the key to individualised, optimised therapy after acute brain injury. Near-infrared spectroscopy (NIRS) offers the potential for non-invasive, continuous bedside measurement of surrogates for these processes. Interest has grown in applying this technique to interpret cerebrovascular pressure reactivity (CVPR), a surrogate of the brain's ability to autoregulate blood flow. We describe a physiological model-based approach to NIRS interpretation which predicts autoregulatory efficiency from a model parameter k_aut. Data from three critically brain-injured patients exhibiting a change in CVPR were investigated. An optimal value for k_aut was determined to minimise the difference between measured and simulated outputs. Optimal values for k_aut appropriately tracked changes in CVPR under most circumstances. Further development of this technique could be used to track CVPR providing targets for individualised management of patients with altered vascular reactivity, minimising secondary neurological insults.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Centre for the Mathematical Modelling of Infectious Diseases
SaME Modelling & Economics
PubMed ID: 22879019
Web of Science ID: 339280100014
URI: http://researchonline.lshtm.ac.uk/id/eprint/2108653

Statistics


Download activity - last 12 months
Downloads since deposit
238Downloads
289Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item