Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations.


Evans, MC; Barnes, J; Nielsen, C; Kim, LG; Clegg, SL; Blair, M; Leung, KK; Douiri, A; Boyes, RG; Ourselin, S; Fox, NC; Alzheimer's Disease Neuroimaging Initiative, ; (2010) Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations. European radiology, 20 (3). pp. 674-82. ISSN 0938-7994 DOI: https://doi.org/10.1007/s00330-009-1581-5

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Abstract

OBJECTIVE: To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. MATERIAL AND METHODS: In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. RESULTS: Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. CONCLUSION: Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 19760240
Web of Science ID: 274544800019
URI: http://researchonline.lshtm.ac.uk/id/eprint/2091

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