Health and economic impact of the seasonal influenza vaccination programme in England.


Baguelin, M; Jit, M; Miller, E; Edmunds, WJ; (2012) Health and economic impact of the seasonal influenza vaccination programme in England. Vaccine. ISSN 0264-410X DOI: 10.1016/j.vaccine.2012.03.019

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Abstract

: BACKGROUND: The seasonal influenza vaccination programme in England targets individuals over 65years old and in clinical risk groups. METHODS: A model of influenza transmission and disease was fitted to weekly primary care consultations due to influenza in a typical pre-pandemic season (2006/2007). Different scenarios were constructed about influenza severity and how well vaccines match circulating strains to assess the impact and cost-effectiveness of the current vaccination programme. RESULTS: A well-matched vaccine may reduce the incidence of laboratory-confirmed influenza illness from 8.2% (95% range 4.3-13%) to 5.9% (95% range 2.9-9.7%), with 56-73% of this due to indirect protection. The programme is likely to be cost-effective unless both low severity and poor matching is assumed. CONCLUSION: The current seasonal influenza vaccination programme appears to substantially reduce disease burden and provides good value for money.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 22446636
Web of Science ID: 303695500016
URI: http://researchonline.lshtm.ac.uk/id/eprint/20687

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