PM Mass Concentration and PM Oxidative Potential in Relation to Carotid Intima-media Thickness.


Tonne, C; Yanosky, JD; Beevers, S; Wilkinson, P; Kelly, FJ; (2012) PM Mass Concentration and PM Oxidative Potential in Relation to Carotid Intima-media Thickness. Epidemiology (Cambridge, Mass), 23 (3). pp. 486-94. ISSN 1044-3983 DOI: https://doi.org/10.1097/EDE.0b013e31824e613e

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Abstract

BACKGROUND: : There is limited evidence on whether particulate matter (PM) can augment the progression of atherosclerosis; furthermore, the specific attributes of PM responsible for health effects are unclear. We developed models to predict exposure to PM <10 ?m (PM10) and also to predict a measure of oxidative potential (the capacity of particles to induce oxidative damage). Our objectives were (1) to estimate the association between PM10 and carotid intima-media thickness, a measure of subclinical atherosclerosis, and (2) to compare this association with that of PM10 weighted by its oxidative potential (PM10*OP).<br/> METHODS: : Analysis was based on 2348 participants of the Whitehall II cohort of British civil servants who had intima-media thickness measured between 2003 and 2005 and lived in Greater London. Weekly PM10 and PM10*OP were predicted at each participant's residence. Primary exposure metrics were defined as PM10 and PM10*OP averaged over the year before scan. We estimated associations between exposure metrics and intima-media thickness using generalized linear regression models.<br/> RESULTS: : An interquartile range increase (5.2 ?gm) in PM10 was associated with a 5.0% (95% confidence interval = 1.9% to 8.3%) increase in intima-media thickness after covariate adjustment. The association for an interquartile range change in PM10*OP (1.5 m) was weaker: 1.2% (0.2% to 2.2%).<br/> CONCLUSIONS: : These findings support a relationship between PM exposure and atherosclerosis. PM weighted by this particular measure of oxidative potential was not more predictive of the extent of atherosclerosis than PM mass concentration.<br/>

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 22450694
Web of Science ID: 302783700019
URI: http://researchonline.lshtm.ac.uk/id/eprint/20671

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