Low drug resistance levels among drug-naive individuals with recent HIV type 1 infection in a rural clinical cohort in southwestern Uganda


Ssemwanga, D; Kapaata, A; Lyagoba, F; Magambo, B; Nanyonjo, M; Mayanja, BN; Parry, CM; Kaleebu, P; (2012) Low drug resistance levels among drug-naive individuals with recent HIV type 1 infection in a rural clinical cohort in southwestern Uganda. AIDS research and human retroviruses, 28 (12). pp. 1784-7. ISSN 0889-2229 DOI: 10.1089/AID.2012.0090

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Abstract

: To investigate the prevalence of transmitted drug resistance (TDR) among individuals with recent HIV-1 infection between February 2004 and January 2010 in a rural clinical cohort, samples from 72 participants were analyzed. Results from the 72 participants showed no protease inhibitor and nucleoside reverse transcriptase inhibitor-associated mutations. One participant (1.4%, 95% CI: 0.04-7.5%) had two nonnucleoside reverse transcriptase inhibitor mutations (G190E and P225H). HIV-1 subtype frequencies were A 22 (30.6%), D 38 (52.8%), and C 1 (1.4%); 11 (15.3%) were A/D unique recombinant forms. Seven years after the scale up of antiretroviral therapy (ART) in a rural clinical cohort in Uganda, the prevalence of TDR among recently HIV-1-infected individuals was low at 1.4%. Since our findings from an HIV study cohort may not be generalizable to the general population, routine TDR surveys in specific populations may be necessary to inform policy on the magnitude and prevention strategies of TDR.<br/>

Item Type: Article
Keywords: nonnucleoside reverse transcriptase inhibitor, adult, antiviral resistance, antiviral therapy, article, cohort analysis, controlled study, female, gene frequency, human, Human immunodeficiency virus 1 infection, major clinical study, male, priority journal, rural area, Uganda, viral genetics, Adolescent, Aged, Anti-HIV Agents, Cohort Studies, Drug Resistance, Viral, Genotype, HIV Infections, HIV-1, Humans, Middle Aged, Molecular Sequence Data, Mutation, Missense, RNA, Viral, Rural Population, Sequence Analysis, DNA, Viral Proteins, Young Adult, Adolescent, Adult, Aged, Anti-HIV Agents, pharmacology, Cohort Studies, Drug Resistance, Viral, Female, Genotype, HIV Infections, virology, HIV-1, classification, genetics, isolation & purification, Humans, Male, Middle Aged, Molecular Sequence Data, Mutation, Missense, RNA, Viral, genetics, Rural Population, Sequence Analysis, DNA, Uganda, Viral Proteins, genetics, Young Adult
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 22616647
Web of Science ID: 311825000037
URI: http://researchonline.lshtm.ac.uk/id/eprint/2064761

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