IgM antibody reactivity to Treponema pallidum in seroconversion and in the serologic response to syphilis treatment


Sato, NS; da Silva Zerbini, LCM; de Melo, CS; da Silveira, EPR; Mantovani, P; Nascimento, MC; Ueda, M; (2012) IgM antibody reactivity to Treponema pallidum in seroconversion and in the serologic response to syphilis treatment. Jornal brasileiro de patologia e medicina laboratorial, 48 (6). pp. 409-414. ISSN 1676-2444 DOI: https://doi.org/10.1590/s1676-24442012000600004

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Abstract

Introduction: The appropriateness of IgM antibody detection in the diagnosis of syphilis has been extensively discussed. Objective: This study aimed at assessing the detection of anti-T. pallidum IgM antibody (TP-IgMAb) in serum samples from patients with recent syphilis in seroconversion and in the monitoring of post-treatment serological response. Methods: Serum samples from 11 individuals. Results: At seroconversion, positive Tp-IgMAb was detected in 10 samples and IgM reactivity previous to Venereal Disease Research Laboratory (VDRL) was detected in one sample. Seroreversion was found in samples from three treated patients with secondary syphilis and in one individual with reinfection. Conclusion: Tp-IgMAb detection proved to be a potential diagnostic marker for active syphilis, and IgM capture enzyme linked immunosorbent assay (ELISA-IgM) performance was similar to VDRL in post-treatment monitoring.

Item Type: Article
Keywords: IgM antibody, Seroconversion, Seroreversion, Syphilis, Treponema pallidum
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
URI: http://researchonline.lshtm.ac.uk/id/eprint/2064758

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