Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi, LC; Spain, SL; Knight, J; Ellinghaus, E; Stuart, PE; Capon, F; Ding, J; Li, Y; Tejasvi, T; Gudjonsson, JE; +193 more... Kang, HM; Allen, MH; McManus, R; Novelli, G; Samuelsson, L; Schalkwijk, J; Ståhle, M; Burden, AD; Smith, CH; Cork, MJ; Estivill, X; Bowcock, AM; Krueger, GG; Weger, W; Worthington, J; Tazi-Ahnini, R; Nestle, FO; Hayday, A; Hoffmann, P; Winkelmann, J; Wijmenga, C; Langford, C; Edkins, S; Andrews, R; Blackburn, H; Strange, A; Band, G; Pearson, RD; Vukcevic, D; Spencer, CC; Deloukas, P; Mrowietz, U; Schreiber, S; Weidinger, S; Koks, S; Kingo, K; Esko, T; Metspalu, A; Lim, HW; Voorhees, JJ; Weichenthal, M; Wichmann, HE; Chandran, V; Rosen, CF; Rahman, P; Gladman, DD; Griffiths, CE; Reis, A; Kere, J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2; Nair, RP; Franke, A; Barker, JN; Abecasis, GR; Elder, JT; Trembath, RC; , COLLABORATORS; Duffin, KC; Helms, C; Goldgar, D; Li, Y; Paschall, J; Malloy, MJ; Pullinger, CR; Kane, JP; Gardner, J; Perlmutter, A; Miner, A; Feng, BJ; Hiremagalore, R; Ike, RW; Christophers, E; Henseler, T; Ruether, A; Schrodi, SJ; Prahalad, S; Guthery, SL; Fischer, J; Liao, W; Kwok, P; Menter, A; Lathrop, GM; Wise, C; Begovich, AB; Onoufriadis, A; Weale, ME; Hofer, A; Salmhofer, W; Wolf, P; Kainu, K; Saarialho-Kere, U; Suomela, S; Badorf, P; Hüffmeier, U; Kurrat, W; Küster, W; Lascorz, J; Mössner, R; Schürmeier-Horst, F; Ständer, M; Traupe, H; Bergboer, JG; den Heijer, M; van de Kerkhof, PC; Zeeuwen, PL; Barnes, L; Campbell, LE; Cusack, C; Coleman, C; Conroy, J; Ennis, S; Fitzgerald, O; Gallagher, P; Irvine, AD; Kirby, B; Markham, T; McLean, WH; McPartlin, J; Rogers, SF; Ryan, AW; Zawirska, A; Giardina, E; Lepre, T; Perricone, C; Martín-Ezquerra, G; Pujol, RM; Riveira-Munoz, E; Inerot, A; Naluai, Å, T; Mallbris, L; Wolk, K; Leman, J; Barton, A; Warren, RB; Young, HS; Ricano-Ponce, I; Trynka, G; Pellett, FJ; Henschel, A; Aurand, M; Bebo, B; Gieger, C; Illig, T; Moebus, S; Jöckel, KH; Erbel, R; Donnelly, P; Peltonen, L; Blackwell, JM; Bramon, E; Brown, MA; Casas, JP; Corvin, A; Craddock, N; Duncanson, A; Jankowski, J; Markus, HS; Mathew, CG; McCarthy, MI; Palmer, CN; Plomin, R; Rautanen, A; Sawcer, SJ; Samani, N; Viswanathan, AC; Wood, NW; Bellenguez, C; Freeman, C; Hellenthal, G; Giannoulatou, E; Pirinen, M; Su, Z; Hunt, SE; Gwilliam, R; Bumpstead, SJ; Dronov, S; Gillman, M; Gray, E; Hammond, N; Jayakumar, A; McCann, OT; Liddle, J; Perez, ML; Potter, SC; Ravindrarajah, R; Ricketts, M; Waller, M; Weston, P; Widaa, S; Whittaker, P; (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature genetics, 44 (12). pp. 1341-8. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.2467

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Abstract

Item Type Article
Keywords caspase recruitment domain signaling protein, DNA directed DNA polymerase beta, immunoglobulin enhancer binding protein, methyl CpG binding protein 2, retinoic acid inducible protein I, STAT3 protein, transcription factor RUNX3, article, controlled study, Europe, gene identification, gene locus, genetic association, genetic susceptibility, genotype, host resistance, human, human cell, innate immunity, macrophage activation, major clinical study, priority journal, psoriasis, CARD Signaling Adaptor Proteins, Core Binding Factor Alpha 3 Subunit, DEAD-box RNA Helicases, European Continental Ancestry Group, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, GTPase-Activating Proteins, Guanylate Cyclase, Humans, Immunity, Innate, Membrane Proteins, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Skin, STAT3 Transcription Factor, T-Lymphocytes, CARD Signaling Adaptor Proteins, genetics, immunology, Core Binding Factor Alpha 3 Subunit, genetics, immunology, DEAD-box RNA Helicases, genetics, immunology, European Continental Ancestry Group, genetics, GTPase-Activating Proteins, genetics, immunology, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanylate Cyclase, genetics, immunology, Humans, Immunity, Innate, genetics, Membrane Proteins, genetics, immunology, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Psoriasis, genetics, immunology, STAT3 Transcription Factor, genetics, immunology, Skin, immunology, T-Lymphocytes, immunology
Faculty and Department Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID 23143594
ISI 311713200013
Official URL http://www.scopus.com/inward/record.url?eid=2-s2.0...
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