Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide.


Oberli, Matthias A; Tamborrini, Marco; Tsai, Yu-Hsuan; Werz, Daniel B; Horlacher, Tim; Adibekian, Alexander; Gauss, Dominik; Möller, Heiko M; Pluschke, Gerd; Seeberger, Peter H; (2010) Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. Journal of the American Chemical Society, 132 (30). pp. 10239-41. ISSN 1520-5126

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Abstract

The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.

Item Type: Article
PubMed ID: 20614885
URI: http://researchonline.lshtm.ac.uk/id/eprint/20464

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