The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi, Tanzania


Mosha, JF; Sturrock, HJW; Brown, JM; Hashim, R; Kibiki, G; Chandramohan, D; Gosling, RD; (2014) The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi, Tanzania. Malaria Journal, 13. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-445

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Abstract

Background: As malaria transmission declines, continued improvements of prevention and control interventions will increasingly rely on accurate knowledge of risk factors and an ability to define high-risk areas and populations at risk for focal targeting of interventions. This paper explores the independent association between living in a hotspot and prospective risk of malaria infection. Methods: Malaria infection status defined by nPCR and AMA-1 status in year 1 were used to define geographic hotspots using two geospatial statistical methods (SaTScan and Kernel density smoothing). Other malaria risk factors for malaria infection were explored by fitting a multivariable model. Results: This study demonstrated that residing in infection hotspot of malaria transmission is an independent predictor of malaria infection in the future. Conclusion: It is likely that targeting such hotspots with better coverage and improved malaria control strategies will result in more cost-efficient uses of resources to move towards malaria elimination.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
PubMed ID: 25413016
Web of Science ID: 346092900001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2031035

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