In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by Artemether-Lumefantrine and Dihydroartemisinin Piperaquine in Burkina Faso.


Baraka, V; Tinto, H; Valea, I; Fitzhenry, R; Delgado-Ratto, C; Mbonye, MK; Van Overmeir, C; Rosanas-Urgell, A; Van Geertruyden, JP; D'Alessandro, U; Erhart, A; (2015) In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by Artemether-Lumefantrine and Dihydroartemisinin Piperaquine in Burkina Faso. Antimicrobial agents and chemotherapy, 59 (1). pp. 734-7. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.03647-14

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Abstract

: Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 25403659
Web of Science ID: 348609500101
URI: http://researchonline.lshtm.ac.uk/id/eprint/2025543

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