Transient signal changes in diffusion-weighted stimulated echoes during neuronal stimulation at 3T.


Goerke, Ute; Möller, Harald E; (2007) Transient signal changes in diffusion-weighted stimulated echoes during neuronal stimulation at 3T. Journal of magnetic resonance imaging : JMRI, 25 (5). pp. 947-56. ISSN 1053-1807

Full text not available from this repository.

Abstract

To develop a sensitive method for detecting minute transient signal changes that can arise due to variations in the extravascular apparent self-diffusion coefficient, D, during neuronal activation. A three-pulse sequence that reads out a moderately diffusion-weighted (DW) primary echo (PRE) and a heavily DW stimulated echo (STE) was employed to investigate whether small transient signal changes in extravascular D occur in response to a visual stimulus. Contributions to signal changes caused by subtle differences in the transient variations of the apparent transverse relaxation constant, T(2), between the PRE and STE were also quantified. On z-maps obtained from the STE, more voxels showed significant stimulus-related signal changes compared to maps of the PRE. The average maximum signal change of the STE was larger than that of the PRE. The observed increase in the relative signal change was independent of the strength of the diffusion weighting. The STE is more sensitive to neuronal activity than the PRE. The discrepancy between the two echoes does not arise from transient changes in D, but from subtle differences in stimulus-related variations of T(2) between the two echoes.

Item Type: Article
PubMed ID: 17410563
URI: http://researchonline.lshtm.ac.uk/id/eprint/20251

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
0Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item