Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.


Minchella, PA; Armitage, AE; Darboe, B; Jallow, MW; Drakesmith, H; Jaye, A; Prentice, AM; McDermid, JM; (2014) Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study. The international journal of tuberculosis and lung disease, 18 (11). pp. 1337-9. ISSN 1027-3719 DOI: https://doi.org/10.5588/ijtld.14.0143

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Abstract

Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August 1992 and 1 June 2002, with 32 incident TB cases identified. Greater hepcidin was associated with significantly increased likelihood of TB after a median time to TB of 6 months. Elucidation of iron-related causal mechanisms and time-sensitive biomarkers that identify individual changes in TB risk are needed.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 25299867
Web of Science ID: 343530200014
URI: http://researchonline.lshtm.ac.uk/id/eprint/2006433

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