Safety of immunization during pregnancy: A review of the evidence of selected inactivated and live attenuated vaccines.


Keller-Stanislawski, B; Englund, JA; Kang, G; Mangtani, P; Neuzil, K; Nohynek, H; Pless, R; Lambach, P; Zuber, P; (2014) Safety of immunization during pregnancy: A review of the evidence of selected inactivated and live attenuated vaccines. Vaccine, 32 (52). pp. 7057-64. ISSN 0264-410X DOI: 10.1016/j.vaccine.2014.09.052

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Abstract

: Vaccine-preventable infectious diseases are responsible for significant maternal, neonatal, and young infant morbidity and mortality. While there is emerging scientific evidence, as well as theoretical considerations, indicating that certain vaccines are safe for pregnant women and fetuses, policy formulation is challenging because of perceived potential risks to the fetus. This report presents an overview of available evidence on pregnant women vaccination safety monitoring in pregnant women, from both published literature and ongoing surveillance programs. Safety data were reviewed for vaccines against diseases which increase morbidity in pregnant women, their fetus or infant as well as vaccines which are used in mass vaccination campaigns against diseases. They include inactivated seasonal and pandemic influenza, mono- and combined meningococcal polysaccharide and conjugated vaccines, tetanus toxoid and acellular pertussis combination vaccines, as well as monovalent or combined rubella, oral poliomyelitis virus and yellow fever vaccines. No evidence of adverse pregnancy outcomes has been identified from immunization of pregnant women with these vaccines.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
TB Centre
PubMed ID: 25285883
Web of Science ID: 348020200007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2006369

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