High Accuracy of Home-Based Community Rapid HIV Testing in Rural Malawi

Molesworth, AM; Ndhlovu, R; Banda, E; Saul, J; Ngwira, B; Glynn, JR; Crampin, AC; French, N; (2010) High Accuracy of Home-Based Community Rapid HIV Testing in Rural Malawi. Journal of acquired immune deficiency syndromes (1999), 55 (5). pp. 625-30. ISSN 1525-4135 DOI: https://doi.org/10.1097/QAI.0b013e3181f98628

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: To assess the performance of rapid HIV antibody tests when used as part of a home-based community wide counseling and testing strategy in northern Malawi.<br/> : A cross-sectional population survey of HIV infection, 2007 to 2008.<br/> : Adults aged 15 years or older in a demographic surveillance area were counseled and then offered an HIV test at their home by government-certified counselors. Two initial rapid tests (Determine and Uni-Gold) were performed on all samples and a third, tie-breaker test (SD Bioline) used to resolve discordant results. All people who wanted to know were posttest-counseled and informed of their results with referral to local clinical services if found to be HIV-positive. Laboratory quality control comprised retesting all positive and every tenth negative venous blood sample collected.<br/> : A total of 10,819 adults provided venous blood samples for HIV testing, of whom 7.5% (813) were HIV-positive. The accuracy of the parallel testing strategy used was high with 99.6% sensitivity, 100.0% specificity, 99.9% positive predictive value, and 99.9% negative predictive value.<br/> : Face-to-face rapid testing by health personnel with minimum training at the client's home performs well when used on a wide scale in the community setting.<br/>

Item Type: Article
Keywords: HIV serodiagnosis, quality control, home care, population surveillance, Malawi, POPULATION, COUNTRIES, ANTIBODY, TRIALS, UGANDA, COST
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 21934554
Web of Science ID: 284147500016
URI: http://researchonline.lshtm.ac.uk/id/eprint/1947


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