Long-term follow-up of the Portuguese Thorotrast study.


dos Santos Silva, I; Jones, M; Malveiro, F; (2005) Long-term follow-up of the Portuguese Thorotrast study. In: Paretzke, HG, (ed.) In: Health Effects of Incorporated Radionuclides (HEIR 2004) - Emphasis on Radium, Thorium, Uranium and Their Daughter Products. GSF - Forschungszentrum, Neuherberg, Germany.

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Abstract

Thorotrast is a radioactive radiological contrast medium used in the 1920-50s. Thorotrast is retained by the reticuloendothelial system with a biological half-life of several hundred years, so that patients administered this contrast medium systemically suffer lifetime exposure to internal alpha-particle radiation. We studied mortality in Portuguese patients who were administered thorotrast and in a comparison group of patients who received non-radioactive contrast agents. A cohort of 1096 systemically-exposed thorotrast patients and 1014 unexposed patients was followed-up to the end of 1996. Mortality was statistically significantly raised among systemically-exposed thorotrast patients relative to those unexposed for all causes, liver cancer, chronic liver disease, other non-neoplastic diseases of the digestive system, neoplastic and non-neoplastic haematological disorders, and non-neoplastic diseases of the respiratory system. Risks for most of these conditions increased significantly with time since first administration remaining high for over 40 years after administration of thorotrast.

Item Type: Book Section
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
URI: http://researchonline.lshtm.ac.uk/id/eprint/19433

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