Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment.


Falcaro, M; Pickles, A; Newbury, DF; Addis, L; Banfield, E; Fisher, SE; Monaco, AP; Simkin, Z; Conti-Ramsden, G; SLI Consortium, ; (2008) Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment. Genes, brain, and behavior, 7 (4). pp. 393-402. ISSN 1601-1848 DOI: https://doi.org/10.1111/j.1601-183X.2007.00364.x

Full text not available from this repository.

Abstract

Deficits in phonological short-term memory and aspects of verb grammar morphology have been proposed as phenotypic markers of specific language impairment (SLI) with the suggestion that these traits are likely to be under different genetic influences. This investigation in 300 first-degree relatives of 93 probands with SLI examined familial aggregation and genetic linkage of two measures thought to index these two traits, non-word repetition and tense marking. In particular, the involvement of chromosomes 16q and 19q was examined as previous studies found these two regions to be related to SLI. Results showed a strong association between relatives' and probands' scores on non-word repetition. In contrast, no association was found for tense marking when examined as a continuous measure. However, significant familial aggregation was found when tense marking was treated as a binary measure with a cut-off point of -1.5 SD, suggestive of the possibility that qualitative distinctions in the trait may be familial while quantitative variability may be more a consequence of non-familial factors. Linkage analyses supported previous findings of the SLI Consortium of linkage to chromosome 16q for phonological short-term memory and to chromosome 19q for expressive language. In addition, we report new findings that relate to the past tense phenotype. For the continuous measure, linkage was found on both chromosomes, but evidence was stronger on chromosome 19. For the binary measure, linkage was observed on chromosome 19 but not on chromosome 16.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 18005161
Web of Science ID: 255286200002
URI: http://researchonline.lshtm.ac.uk/id/eprint/1922

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
283Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item