An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation


Wilhelm, C; Hirota, K; Stieglitz, B; van Snick, J; Tolaini, M; Lahl, K; Sparwasser, T; Helmby, H; Stockinger, B; (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature immunology, 12 (11). 1071-U73. ISSN 1529-2908 DOI: https://doi.org/10.1038/ni.2133

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Abstract

Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 21983833
Web of Science ID: 296500100012
URI: http://researchonline.lshtm.ac.uk/id/eprint/19130

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