Identification and characterisation of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.


Lin, WY; Camp, NJ; Ghoussaini, M; Beesley, J; Michailidou, K; Hopper, JL; Apicella, C; Southey, MC; Stone, J; Schmidt, MK; Broeks, A; Van't Veer, LJ; Th Rutgers, EJ; Muir, K; Lophatananon, A; Stewart-Brown, S; Siriwanarangsan, P; Fasching, PA; Haeberle, L; Ekici, AB; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Fletcher, O; Johnson, N; Bolla, MK; Wang, Q; Dennis, J; Sawyer, EJ; Cheng, T; Tomlinson, I; Kerin, MJ; Miller, N; Marmé, F; Surowy, HM; Burwinkel, B; Guénel, P; Truong, T; Menegaux, F; Mulot, C; Bojesen, SE; Nordestgaard, BG; Nielsen, SF; Flyger, H; Benitez, J; Zamora, MP; Arias Perez, JI; Menéndez, P; González-Neira, A; Pita, G; Alonso, MR; Alvarez, N; Herrero, D; Anton-Culver, H; Brenner, H; Dieffenbach, AK; Arndt, V; Stegmaier, C; Meindl, A; Lichtner, P; Schmutzler, RK; Müller-Myhsok, B; Brauch, H; Brüning, T; Ko, YD; GENICA Network, ; Tessier, DC; Vincent, D; Bacot, F; Nevanlinna, H; Aittomäki, K; Blomqvist, C; Khan, S; Matsuo, K; Ito, H; Iwata, H; Horio, A; Bogdanova, NV; Antonenkova, NN; Dörk, T; Lindblom, A; Margolin, S; Mannermaa, A; Kataja, V; Kosma, VM; Hartikainen, JM; kConFab Investigators, ; Australian Ovarian Cancer Study Group, ; Wu, AH; Tseng, CC; Van Den Berg, D; Stram, DO; Neven, P; Wauters, E; Wildiers, H; Lambrechts, D; Chang-Claude, J; Rudolph, A; Seibold, P; Flesch-Janys, D; Radice, P; Peterlongo, P; Manoukian, S; Bonanni, B; Couch, FJ; Wang, X; Vachon, C; Purrington, K; Giles, GG; Milne, RL; Mclean, C; Haiman, CA; Henderson, BE; Schumacher, F; Le Marchand, L; Simard, J; Goldberg, MS; Labrèche, F; Dumont, M; Teo, SH; Yip, CH; Hassan, N; Vithana, EN; Kristensen, V; Zheng, W; Deming-Halverson, S; Shrubsole, MJ; Long, J; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Kauppila, S; Andrulis, IL; Knight, JA; Glendon, G; Tchatchou, S; Devilee, P; Tollenaar, RA; Seynaeve, C; Van Asperen, CJ; García-Closas, M; Figueroa, J; Lissowska, J; Brinton, L; Czene, K; Darabi, H; Eriksson, M; Brand, JS; Hooning, MJ; Hollestelle, A; Van Den Ouweland, AM; Jager, A; Li, J; Liu, J; Humphreys, K; Shu, XO; Lu, W; Gao, YT; Cai, H; Cross, SS; Reed, MW; Blot, W; Signorello, LB; Cai, Q; Pharoah, PD; Perkins, B; Shah, M; Blows, FM; Kang, D; Yoo, KY; Noh, DY; Hartman, M; Miao, H; Chia, KS; Putti, TC; Hamann, U; Luccarini, C; Baynes, C; Ahmed, S; Maranian, M; Healey, CS; Jakubowska, A; Lubinski, J; Jaworska-Bieniek, K; Durda, K; Sangrajrang, S; Gaborieau, V; Brennan, P; Mckay, J; Slager, S; Toland, AE; Yannoukakos, D; Shen, CY; Hsiung, CN; Wu, PE; Ding, SL; Ashworth, A; Jones, M; Orr, N; Swerdlow, AJ; Tsimiklis, H; Makalic, E; Schmidt, DF; Bui, QM; Chanock, SJ; Hunter, DJ; Hein, R; Dahmen, N; Beckmann, L; Aaltonen, K; Muranen, TA; Heikkinen, T; Irwanto, A; Rahman, N; Turnbull, CA; Breast and Ovarian Cancer Susceptibility (BOCS) Study, ; Waisfisz, Q; Meijers-Heijboer, HE; Adank, MA; Van Der Luijt, RB; Hall, P; Chenevix-Trench, G; Dunning, A; Easton, DF; Cox, A; (2014) Identification and characterisation of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Human molecular genetics, 24 (1). pp. 285-98. ISSN 0964-6906 DOI: https://doi.org/10.1093/hmg/ddu431

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Abstract

: Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regression models adjusting for study and ancestry principal components. The SNPs retained in the final model were investigated further in data from nine genome-wide association studies (GWAS) comprising in total 10 052 case and 12 575 control subjects. The most significant association signal observed in European subjects was for the imputed intronic SNP rs1830298 in ALS2CR12 (telomeric to CASP8), with per allele odds ratio and 95% confidence interval [OR (95% confidence interval, CI)] for the minor allele of 1.05 (1.03-1.07), P = 1 × 10(-5). Three additional independent signals from intronic SNPs were identified, in CASP8 (rs36043647), ALS2CR11 (rs59278883) and CFLAR (rs7558475). The association with rs1830298 was replicated in the imputed results from the combined GWAS (P = 3 × 10(-6)), yielding a combined OR (95% CI) of 1.06 (1.04-1.08), P = 1 × 10(-9). Analyses of gene expression associations in peripheral blood and normal breast tissue indicate that CASP8 might be the target gene, suggesting a mechanism involving apoptosis.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 25168388
Web of Science ID: 350135400023
URI: http://researchonline.lshtm.ac.uk/id/eprint/1910959

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