National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010.


Lee, AC; Katz, J; Blencowe, H; Cousens, S; Kozuki, N; Vogel, JP; Adair, L; Baqui, AH; Bhutta, ZA; Caulfield, LE; Christian, P; Clarke, SE; Ezzati, M; Fawzi, W; Gonzalez, R; Huybregts, L; Kariuki, S; Kolsteren, P; Lusingu, J; Marchant, T; Merialdi, M; Mongkolchati, A; Mullany, LC; Ndirangu, J; Newell, ML; Nien, JK; Osrin, D; Roberfroid, D; Rosen, HE; Sania, A; Silveira, MF; Tielsch, J; Vaidya, A; Willey, BA; Lawn, JE; Black, RE; CHERG SGA-Preterm Birth Working Group, ; (2013) National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob Health, 1 (1). e26-36. ISSN 2214-109X DOI: https://doi.org/10.1016/S2214-109X(13)70006-8

[img]
Preview
Text - Published Version
License:

Download (545kB) | Preview

Abstract

BACKGROUND National estimates for the numbers of babies born small for gestational age and the comorbidity with preterm birth are unavailable. We aimed to estimate the prevalence of term and preterm babies born small for gestational age (term-SGA and preterm-SGA), and the relation to low birthweight (<2500 g), in 138 countries of low and middle income in 2010. METHODS Small for gestational age was defined as lower than the 10th centile for fetal growth from the 1991 US national reference population. Data from 22 birth cohort studies (14 low-income and middle-income countries) and from the WHO Global Survey on Maternal and Perinatal Health (23 countries) were used to model the prevalence of term-SGA births. Prevalence of preterm-SGA infants was calculated from meta-analyses. FINDINGS In 2010, an estimated 32·4 million infants were born small for gestational age in low-income and middle-income countries (27% of livebirths), of whom 10·6 million infants were born at term and low birthweight. The prevalence of term-SGA babies ranged from 5·3% of livebirths in east Asia to 41·5% in south Asia, and the prevalence of preterm-SGA infants ranged from 1·2% in north Africa to 3·0% in southeast Asia. Of 18 million low-birthweight babies, 59% were term-SGA and 41% were preterm-SGA. Two-thirds of small-for-gestational-age infants were born in Asia (17·4 million in south Asia). Preterm-SGA babies totalled 2·8 million births in low-income and middle-income countries. Most small-for-gestational-age infants were born in India, Pakistan, Nigeria, and Bangladesh. INTERPRETATION The burden of small-for-gestational-age births is very high in countries of low and middle income and is concentrated in south Asia. Implementation of effective interventions for babies born too small or too soon is an urgent priority to increase survival and reduce disability, stunting, and non-communicable diseases. FUNDING Bill & Melinda Gates Foundation by a grant to the US Fund for UNICEF to support the activities of the Child Health Epidemiology Reference Group (CHERG).

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Tropical Epidemiology Group
PubMed ID: 25103583
Web of Science ID: 336422200010
URI: http://researchonline.lshtm.ac.uk/id/eprint/1878041

Statistics


Download activity - last 12 months
Downloads since deposit
257Downloads
307Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item