The effect of prenatal perfluorinated chemicals exposures on pediatric atopy

Wang, IJ; Hsieh, WS; Chen, CY; Fletcher, T; Lien, GW; Chiang, HL; Chiang, CF; Wu, TN; Chen, PC; (2011) The effect of prenatal perfluorinated chemicals exposures on pediatric atopy. Environmental research, 111 (6). pp. 785-791. ISSN 0013-9351 DOI:

Full text not available from this repository.


Background: The role of perfluorinated compounds (PFCs) in the immune system and allergic diseases is not well-known. This study examined the effects of pre-natal exposure to PFCs on immunoglobulin E (IgE) levels and atopic dermatitis (AD). Methods: In Taiwan Birth Panel cohort study, newborns with cord blood and pen-natal factors (i.e. birth body weight, weeks of gestation, and type of delivery) gathered at birth were evaluated. At the age of 2 years, information on the development of AD, environmental exposures, and serum total IgE were collected. The AD and non-AD children were compared for the concentration of cord blood serum PFCs measured by Ultra-performance liquid chromatography/triple-quadrupole mass (UPLC-MS/MS). Correlations among cord blood IgE, serum total IgE at 2 years of age, and cord blood PFC levels were made. Results: Of 244 children who completed the follow-up and specimen collections, 43 (17.6%) developed AD. Concentrations of cord blood serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) were median (range) 1.71 (0.75-17.40), 5.50 (0.11-48.36), 2.30 (0.38-63.87), and 0.035 (0.035-0.420) ng/mL, respectively. PFOA and PFOS levels positively correlated with cord blood IgE levels (per In-unit: beta=0.134 KU/l, p=0.047 for PFOA; beta=0.161 KU/l, p=0.017 for PFOS). Analyses stratified by gender revealed that PFOA and PFOS levels positively correlated with cord blood IgE levels only in boys (per In-unit: beta=0.206 KU/l, p=0.025 for PFOA; beta=0.175 KU/l, p=0.053 for PFOS). When dividing cord blood serum PFCs into quartiles in the fully adjusted models, AD had no significant association with PFOS. Conclusions: Pre-natal PFOA and PFOS exposures positively correlated with cord blood IgE levels. (C) 2011 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Cord blood, Perfluorinated compounds, IgE, Atopic dermatitis, activated-receptor-alpha, perfluorooctane sulfonate pfos, polyfluoroalkyl compounds, serum concentrations, nhanes 1999-2000, national-health, blood-samples, us population, in-utero, acid, Child, Preschool, Cohort Studies, Dermatitis, Atopic, epidemiology, etiology, immunology, Female, Fetal Blood, chemistry, immunology, Fluorocarbons, blood, immunology, toxicity, Humans, Immunoglobulin E, blood, immunology, Infant, Newborn, Male, Maternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, chemically induced, epidemiology, immunology, Sex Factors, Taiwan
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 21601844
Web of Science ID: 293671300008


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item