Methodological Issues in Sampling the Local Immune System of the Female Genital Tract in the Context of HIV Prevention Trials.


Jespers, V; Francis, SC; van de Wijgert, J; Crucitti, T; (2010) Methodological Issues in Sampling the Local Immune System of the Female Genital Tract in the Context of HIV Prevention Trials. American journal of reproductive immunology (New York, NY. ISSN 1046-7408 DOI: https://doi.org/10.1111/j.1600-0897.2010.00938.x

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Abstract

Citation Jespers V, Francis SC, van de Wijgert J, Crucitti T. Methodological issues in sampling the local immune system of the female genital tract in the context of HIV prevention trials. Am J Reprod Immunol 2010 The spread of HIV continues unabated in the most vulnerable populations of the world. HIV prevention methods, such as a vaginal microbicide, a mucosal vaccine, pre-exposure prophylaxis or a vaccine, are urgently needed in the fight against new infections. We must make a commitment to supporting innovative research and product design, so that one or more of these products provide a halt to the spread of HIV. Above all, these products should be proven to be safe and not negatively disturb the local immune system in a way that facilitates or enhances heterosexual transmission of HIV. HIV specific and non specific cellular and humoral local vaginal immunity must be assessed in clinical trials when testing prevention products for safety or efficacy. A proven, well-documented and standardized sampling strategy will provide high quality data to be able to assess both safety and local immune responses. In this paper, we will discuss methods for vaginal immunology sampling in the context of clinical trials.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 21199064
Web of Science ID: 287037200025
URI: http://researchonline.lshtm.ac.uk/id/eprint/1863

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