[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein]


Timofeev, AV; Kondrat'Eva, L; Karganova, GG; Stephenson, J; (2001) [Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein]. Voprosy virusologii, 46 (1). pp. 22-4. ISSN 0507-4088

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Abstract

Three intramuscular injections (50 micrograms each) with bacterial plasmid pMV45 carrying nonstructural gene of NS1 protein of tick-borne encephalitis (TBE) virus protected 88% Balb/c mice from lethal challenge with the virus. Antibodies to NS1 nonstructural protein were detected in the sera of vaccinated mice after the challenge. Absence of antibodies to E structural protein indicated absence of manifest infectious process in mice vaccinated with plasmid and challenged with a lethal dose of TBE virus.

Item Type: Article
Keywords: Animal, Antibodies, Viral, blood, Cercopithecus aethiops, Encephalitis Viruses, Tick-Borne, genetics, English Abstract, Mice, Mice, Inbred BALB C, Plasmids, administration & dosage, Vero Cells, Viral Envelope Proteins, immunology, Viral Nonstructural Proteins, genetics, immunology, Viral Vaccines, administration & dosage
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 11233282
URI: http://researchonline.lshtm.ac.uk/id/eprint/18489

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