The risk of subsequent primary cancers after colorectal cancer in South East England


Evans, H; Møller, H; Robinson, D; Lewis, CM; Bell, CMJ; Hodgson, SV; (2002) The risk of subsequent primary cancers after colorectal cancer in South East England. Gut, 50 (5). pp. 647-52. ISSN 0017-5749 DOI: https://doi.org/10.1136/gut.50.5.647

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Abstract

BACKGROUND: Multiple cancers may occur in an individual because of a genetic predisposition, environmental exposure, cancer therapy, or immunological deficiency. Colorectal cancer is one of the most commonly diagnosed cancers, and inherited factors play an important role in its aetiology. AIMS: To characterise the occurrence of multiple primary cancers in patients diagnosed with colorectal cancer and explore the possibility of a common aetiology for different cancer sites. PATIENTS: The Thames Cancer Registry database was used to identify patients with a first colorectal cancer, resident in the North or South Thames region, diagnosed between 1 January 1961 and 31 December 1995. A total of 127 281 patients were included, 61 433 men and 65 848 women. METHODS: Observed numbers of cancers occurring after the diagnosis of colorectal cancer were compared with expected numbers, calculated using appropriate age, sex, and period specific rates, to obtain standardised incidence ratios. The occurrence of colorectal cancers subsequent to cancers at other sites was also examined. RESULTS: Small intestinal cancer was significantly increased in men diagnosed with colorectal cancer before the age of 60 years and in women diagnosed with colorectal cancer after the age of 65 years. Colorectal cancer was also significantly increased after a first diagnosis of cancer of the small intestine. Other cancer sites with a significant increase after colorectal cancer included the cervix uteri, corpus uteri, and ovary. CONCLUSIONS: Patients with colorectal cancer are at increased risk of developing cancer at a number of other sites. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes.

Item Type: Article
Keywords: Adult, Aged, Colorectal Neoplasms, epidemiology, etiology, Digestive System Neoplasms, epidemiology, etiology, England, epidemiology, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genital Neoplasms, Female, epidemiology, etiology, Human, Incidence, Intestine, Small, Male, Middle Age, Neoplasms, Second Primary, epidemiology, etiology, Registries, Risk Assessment, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 11950810
Web of Science ID: 175119800014
URI: http://researchonline.lshtm.ac.uk/id/eprint/18451

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