Risk factors for symptomatic and asymptomatic norovirus infection in the community.


Phillips, G; Tam, CC; Rodrigues, LC; Lopman, B; (2011) Risk factors for symptomatic and asymptomatic norovirus infection in the community. Epidemiology and infection, 139 (11). pp. 1676-86. ISSN 0950-2688 DOI: 10.1017/S0950268810002839

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Abstract

: The objective of this study was to investigate risk factors for norovirus-associated infectious intestinal disease (IID) and asymptomatic norovirus infection. Individuals with IID and healthy controls were recruited in a community-based study in England (1993-1996). This is the first risk-factor study to use viral load measurements, generated by real-time RT-PCR, to identify cases of norovirus-associated IID and asymptomatic infections. Using multivariable logistic regression the main risk factor identified for norovirus-associated IID was contact with a person with IID symptoms. Infectious contacts accounted for 54% of norovirus cases in young children and 39% of norovirus cases in older children and adults. For young children, contacts outside the household presented the highest risk; for older children and adults, the highest risk was associated with child contacts inside the household. Foreign travel and consumption of shellfish increased the risk of norovirus-associated IID. Lifestyle and dietary factors were associated with a decreased risk of both norovirus-associated IID and asymptomatic infection. No risk factors were identified for asymptomatic norovirus infection.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 21205382
Web of Science ID: 296428300005
URI: http://researchonline.lshtm.ac.uk/id/eprint/1809

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