Do shoes reduce hookworm infection in school-aged children on Pemba Island, Zanzibar? A pragmatic trial


Bird, C; Ame, S; Albonico, M; Bickle, Q; (2014) Do shoes reduce hookworm infection in school-aged children on Pemba Island, Zanzibar? A pragmatic trial. Transactions of the Royal Society of Tropical Medicine and Hygiene, 108 (5). pp. 297-304. ISSN 0035-9203 DOI: https://doi.org/10.1093/trstmh/tru037

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Abstract

Background: A non-blinded, cluster randomised controlled trial to test whether footwear reduces prevalence and intensity of hookworm infection in school-aged children on Pemba Island, Zanzibar. Methods: Six schools were randomised to receive shoes and standard care (deworming with albendazole and health education) and six control schools to receive standard care only. Children provided a stool sample to assess prevalence and intensity of infection with soil transmitted helminthiases (Ascaris lumbricoides, Trichuris trichiura and hookworm). Shoes were then distributed to pupils in the intervention schools; deworming took place as part of the governments mass drug administration programme and a further round of stool samples were collected six months later. Results: Nine hundred and fifteen children were traced at follow-up (1056 at baseline). As many children wore shoes in the control arm as the intervention arm. There was no difference in hookworm prevalence (23.4 for intervention schools, 21.3 for control schools, p=0.48), and no difference in mean hookworm infection in eggs/gram of stool (18, 136 in intervention schools, 18, 729 in control schools, p=0.23). Shoe-wearing increased across all schools, from 47.4 to 82.4. If a child wore shoes at the end of the study, the relative risk of hookworm infection was 0.7 (CI 0.53-0.91). Conclusion: Due to contamination, the trial could not conclude that shoes were protective against hookworm infection but the intervention led to behavioural change, and observational data suggest that shoes are protective against hookworm.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 24603321
Web of Science ID: 334754200010
URI: http://researchonline.lshtm.ac.uk/id/eprint/1805374

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