Classification of HHV-6A and HHV-6B as distinct viruses


Ablashi, D; Agut, H; Alvarez-Lafuente, R; Clark, DA; Dewhurst, S; Diluca, D; Flamand, L; Frenkel, N; Gallo, R; Gompels, UA; Hollsberg, P; Jacobson, S; Luppi, M; Lusso, P; Malnati, M; Medveczky, P; Mori, Y; Pellett, PE; Pritchett, JC; Yamanishi, K; Yoshikawa, T; (2013) Classification of HHV-6A and HHV-6B as distinct viruses. Archives of virology, 159 (5). pp. 863-870. ISSN 0304-8608 DOI: https://doi.org/10.1007/s00705-013-1902-5

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Abstract

Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

Item Type: Article
Keywords: Genetic Variation, Herpesvirus 6, Human, classification, genetics, Humans, Roseolovirus Infections, epidemiology, immunology, virology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
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PubMed ID: 24193951
Web of Science ID: 335777600003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1805341

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