Classification of HHV-6A and HHV-6B as distinct viruses

Ablashi, D; Agut, H; Alvarez-Lafuente, R; Clark, DA; Dewhurst, S; Diluca, D; Flamand, L; Frenkel, N; Gallo, R; Gompels, UA; Hollsberg, P; Jacobson, S; Luppi, M; Lusso, P; Malnati, M; Medveczky, P; Mori, Y; Pellett, PE; Pritchett, JC; Yamanishi, K; Yoshikawa, T; (2013) Classification of HHV-6A and HHV-6B as distinct viruses. Archives of virology, 159 (5). pp. 863-870. ISSN 0304-8608 DOI:

Text - Accepted Version

Download (167kB) | Preview


Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

Item Type: Article
Keywords: Genetic Variation, Herpesvirus 6, Human, classification, genetics, Humans, Roseolovirus Infections, epidemiology, immunology, virology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Related URLs:
PubMed ID: 24193951
Web of Science ID: 335777600003


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item