Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.

Gadalla, Nahla B; Adam, Ishag; Elzaki, Salah-Eldin; Bashir, Sahar; Mukhtar, Izdihar; Oguike, Mary; Gadalla, Amal; Mansour, Fathi; Warhurst, David; El-Sayed, Badria B; +1 more... Sutherland, Colin J; (2011) Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine. Antimicrobial agents and chemotherapy, 55 (11). pp. 5408-5411. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.05102-11

Abstract

Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology > Dept of Immunology and Infection (-2019) Faculty of Infectious and Tropical Diseases > Department of Infection Biology > Dept of Pathogen Molecular Biology (-2019) Faculty of Infectious and Tropical Diseases > Department of Infection Biology
Research Centre	Antimicrobial Resistance Centre (AMR) Malaria Centre
PubMed ID	21896916
ISI	296375600071
Related URLs	OA Location