Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.


Gadalla, NB; Adam, I; Elzaki, SE; Bashir, S; Mukhtar, I; Oguike, M; Gadalla, A; Mansour, F; Warhurst, D; El-Sayed, BB; Sutherland, CJ; (2011) Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine. Antimicrobial agents and chemotherapy, 55 (11). pp. 5408-11. ISSN 0066-4804 DOI: 10.1128/AAC.05102-11

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Abstract

: Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 21896916
Web of Science ID: 296375600071
URI: http://researchonline.lshtm.ac.uk/id/eprint/180

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