Leukaemia and occupation: a New Zealand Cancer Registry-based casecontrol Study

McLean, D; Mannetje, A; Dryson, E; Walls, C; McKenzie, F; Maule, M; Cheng, S; Cunningham, C; Kromhout, H; Boffetta, P; Blair, A; Pearce, N; (2009) Leukaemia and occupation: a New Zealand Cancer Registry-based casecontrol Study. International journal of epidemiology, 38 (2). pp. 594-606. ISSN 0300-5771 DOI: https://doi.org/10.1093/ije/dyn220

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Background To examine the association between occupation and leukaemia. Methods We interviewed 225 cases (aged 2075 years) notified to the New Zealand Cancer Registry during 200304, and 471 controls randomly selected from the Electoral Roll collecting demographic details, information on potential confounders and a comprehensive employment history. Associations between occupation and leukaemia were analysed using logistic regression adjusted for gender, age, ethnicity and smoking. Results Elevated odds ratios (ORs) were observed in agricultural sectors including horticulture/fruit growing (OR: 2.62, 95 confidence interval (CI): 1.51, 4.55), plant nurseries (OR: 7.51, 95 CI: 1.85, 30.38) and vegetable growing (OR: 3.14, 95 CI: 1.18, 8.40); and appeared greater in women (ORs: 4.71, 7.75 and 7.98, respectively). Elevated ORs were also observed in market farmers/crop growers (OR: 1.84, 95 CI: 1.12, 3.02), field crop/vegetable growers (OR: 3.98, 95 CI: 1.46, 10.85), market gardeners (OR: 5.50, 95 CI: 1.59, 19.02), and nursery growers/workers (OR: 4.23, 95 CI: 1.34, 13.35); also greater in women (ORs: 3.48, 7.62, 15.74 and 11.70, respectively). These elevated ORs were predominantly for chronic lymphocytic leukaemia (CLL). Several associations persisted after semi-Bayes adjustment. Elevated ORs were observed in rubber/plastics products machine operators (OR: 3.76, 95 CI: 1.08, 13.08), predominantly in plastic product manufacturing. CLL was also elevated in tailors and dressmakers (OR: 7.01, 95 CI: 1.78, 27.68), cleaners (OR: 2.04, 95 CI: 1.00, 4.14) and builders labourers (OR: 4.03, 95 CI: 1.30, 12.53). Conclusions These findings suggest increased leukaemia risks associated with certain agricultural, manufacturing, construction and service occupations in New Zealand.

Item Type: Article
Keywords: Adult, Age Distribution, Aged, Agricultural Workers' Diseases, epidemiology, Case-Control Studies, Chemical Industry, Female, Humans, Leukemia, epidemiology, etiology, Male, Middle Aged, New Zealand, epidemiology, Occupational Diseases, epidemiology, Occupations, Registries, Sex Distribution, Textile Industry, Young Adult
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18953052
Web of Science ID: 264890300038
URI: http://researchonline.lshtm.ac.uk/id/eprint/1788


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