Farm exposure in utero may protect against asthma, hay fever and eczema


Douwes, J; Cheng, S; Travier, N; Cohet, C; Niesink, A; McKenzie, J; Cunningham, C; le Gros, G; von Mutius, E; Pearce, N; (2008) Farm exposure in utero may protect against asthma, hay fever and eczema. The European respiratory journal, 32 (3). pp. 603-611. ISSN 0903-1936 DOI: https://doi.org/10.1183/09031936.00033707

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Abstract

The aim of the present study was to assess which factors contribute to the lower prevalence of allergic diseases in farmers' children, and the importance of timing of exposure. In a cross-sectional questionnaire survey, asthma symptoms, hay fever and eczema were assessed, as well as current, early and prenatal farm-related exposures in 1,333 farmers' children and 566 reference children aged 5-17 yrs. Farmers' children had a lower incidence of asthma symptoms and eczema. Current and maternal exposure during pregnancy to animals and/or grain and hay reduced the risk of asthma symptoms, hay fever and eczema. The exposure-response association for maternal exposure was nonlinear for most outcomes. After mutual adjustment, the effects of prenatal exposure remained unchanged whereas current exposure remained protective only for asthma medication, asthma ever and hay fever. Exposure during the first 2 yrs was not associated with symptoms, after controlling for prenatal exposure. A combination of prenatal and current exposure was most strongly associated with wheeze (odds ratio (OR) 0.48, 95% confidence interval (CI) 0.28-0.80), asthma medication (OR 0.50, 95% Cl 0.30-0.82), asthma ever (OR 0.50, 95% Cl 0.33-0.76), hay fever (OR 0.47, 95% Cl 0.30-0.73) and eczema (OR 0.46, 95% Cl 0.30-0.70). Prenatal exposure may contribute to the low prevalence of asthma, hay fever and eczema in farmers' children, but continued exposure may be required to maintain optimal protection.

Item Type: Article
Keywords: Adolescent, Agriculture, Animals, Asthma, epidemiology, immunology, prevention & control, Cattle, Child, Child, Preschool, Cross-Sectional Studies, Dairying, Eczema, epidemiology, immunology, prevention & control, Female, Health Surveys, Humans, Male, Occupational Exposure, Odds Ratio, Pregnancy, Prenatal Exposure Delayed Effects, immunology, Prevalence, Rhinitis, Allergic, Seasonal, epidemiology, immunology, prevention & control
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18448493
Web of Science ID: 259433100012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1782

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