High risk occupations for non-Hodgkin's lymphoma in New Zealand: case-control study

Mannetje, A; Dryson, E; Walls, C; McLean, D; McKenzie, F; Maule, M; Cheng, S; Cunningham, C; Kromhout, H; Boffetta, P; Blair, A; Pearce, N; (2008) High risk occupations for non-Hodgkin's lymphoma in New Zealand: case-control study. Occupational and environmental medicine, 65 (5). pp. 354-363. ISSN 1351-0711 DOI: https://doi.org/10.1136/oem.2007.035014

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Objectives: Previous studies into occupational risk factors for non-Hodgkin's lymphoma (NHL) in New Zealand have indicated that farmers and meat workers are at increased risk for these neoplasms. A new nationwide case-control study was conducted to assess whether previously observed associations persist and to identify other occupations that may contribute to the risk of NHL in the New Zealand population. Methods: A total of 291 incident cases of NHL (age 25 70 years) notified to the New Zealand Cancer Registry during 2003 and 2004, and 471 population controls, were interviewed face-to-face. The questionnaire collected demographic information and a full occupational history. The relative risk for NHL associated with ever being employed in particular occupations and industries was calculated by unconditional logistic regression adjusting for age, sex, smoking, ethnicity and socioeconomic status. Estimates were subsequently semi-Bayes adjusted to account for the large number of occupations and industries being considered. Results: An elevated NHL risk was observed for field crop and vegetable growers (OR 2.74, 95% CI 1.04 to 7.25) and horticulture and fruit growing (OR 2.28, 95% CI 1.37 to 3.79), particularly for women (OR 3.44, 95% CI 0.62 to 18.9; OR 3.15, 95% CI 1.50 to 6.61). Sheep and dairy farming was not associated with an increased risk of NHL. Meat processors had an elevated risk (OR 1.97, 95% CI 0.97 to 3.97), as did heavy truck drivers (OR 1.98, 95% CI 0.92 to 4.24), workers employed in metal product manufacturing (OR 1.92, 95% CI 1.12 to 3.28) and cleaners (OR 2.11, 95% CI 1.21 to 3.65). After semi-Bayes adjustment the elevated risks for horticulture and fruit growing, metal product manufacturing and cleaners remained statistically significant, representing the most robust findings of this study. Conclusions: This study has confirmed that crop farmers and meat workers remain high risk occupations for NHL in New Zealand, and has identified several other occupations and industries of high NHL risk that merit further study.

Item Type: Article
Keywords: Adult, Aged, Agriculture, Case-Control Studies, Female, Humans, Logistic Models, Lymphoma, Non-Hodgkin, etiology, prevention & control, Male, Meat-Packing Industry, Middle Aged, New Zealand, Occupational Diseases, etiology, prevention & control, Occupational Exposure, analysis, Occupations, statistics & numerical data, Questionnaires, Risk Assessment, methods, Risk Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18032530
Web of Science ID: 255120600012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1778


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