Will the enigma of Francisella tularensis virulence soon be solved?

Titball, RW; Johansson, A; Forsman, M; (2003) Will the enigma of Francisella tularensis virulence soon be solved? Trends in microbiology, 11 (3). pp. 118-123. ISSN 0966-842X DOI: https://doi.org/10.1016/s0966-842x(03)00020-9

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Francisella tularensis is one of the most infectious bacterial pathogens known and is the causative agent of the zoonotic disease tularemia. In spite of the importance of this pathogen little is known about its virulence mechanisms. However, it is clear that the bacterium is an intracellular pathogen, replicating mainly in macrophages, with replication in amoebae also having been reported. The genome sequence of a high virulence strain of F tularensis is close to completion and when available, will stimulate further research into virulence mechanisms.

Item Type: Article
Keywords: Macrophages, tularemia, growth, identification, novicida, strains, pcr, Acanthamoeba, microbiology, Animal, Bacterial Proteins, genetics, metabolism, Cell Line, Francisella tularensis, genetics, growth & development, pathogenicity, Gene Expression Regulation, Bacterial, Guinea Pigs, Human, Macrophages, microbiology, Mice, Rabbits, Tularemia, microbiology, Virulence, genetics
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 12648943
Web of Science ID: 182149800008
URI: http://researchonline.lshtm.ac.uk/id/eprint/17741


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