Salmonella vaccines for use in humans: present and future perspectives


Garmory, HS; Brown, KA; Titball, RW; (2002) Salmonella vaccines for use in humans: present and future perspectives. FEMS microbiology reviews, 26 (4). pp. 339-53. ISSN 0168-6445 DOI: 10.1016/S0168-6445(02)00113-4

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Abstract

In recent years there has been significant progress in the development of attenuated Salmonella enterica serovar Typhi strains as candidate typhoid fever vaccines. In clinical trials these vaccines have been shown to be well tolerated and immunogenic. For example, the attenuated S. enterica var. Typhi strains CVD 908-htrA (aroC aroD htrA), Ty800 (phoP phoQ) and chi4073 (cya crp cdt) are all promising candidate typhoid vaccines. In addition, clinical trials have demonstrated that S. enterica var. Typhi vaccines expressing heterologous antigens, such as the tetanus toxin fragment C, can induce immunity to the expressed antigens in human volunteers. In many cases, the problems associated with expression of antigens in Salmonella have been successfully addressed and the future of Salmonella vaccine development is very promising.

Item Type: Article
Keywords: typhoid vaccine, Salmonella vaccine, attenuated live carrier, Enterica serovar typhi, toxin fragment-c, live-attenuated, salmonella, hepatitis-b virus, glutathione-s-transferase, controlled field trial, oral dna vaccine, macrophage-inducible, expression, heat-labile enterotoxin, cholera hybrid vaccine
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 12413664
Web of Science ID: 179131100002
URI: http://researchonline.lshtm.ac.uk/id/eprint/17736

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