WISDOM: history and early demise - was it inevitable?


Vickers, M; Meade, T; Darbyshire, J; (2002) WISDOM: history and early demise - was it inevitable? Climacteric, 5 (4). pp. 317-25. ISSN 1369-7137 DOI: https://doi.org/10.1080/713605309

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Abstract

In 1989, the UK Medical Research Council (MRC) agreed that, if feasible, a randomized controlled trial to assess the long-term risks and benefits of hormone replacement therapy (HRT) was a priority. Feasibility work began in 1990 and demonstrated that a large-scale multicenter trial was possible. An application for funding for a main trial was submitted to MRC in 1993 and, after extensive review, funding was released in late 1996. Set-up work for the trial - the Women's International Study of long Duration Oestrogen after Menopause (WISDOM) - began in 1997 with recruitment in 1999. In October 2002, following the early discontinuation of one arm of the US Women's Health Initiative HRT trial, the MRC decided to stop the WISDOM trial. This article, by the principal UK investigators of WISDOM, sets out the background and history of the trial.

Item Type: Article
Keywords: hormone replacement therapy, randomized controlled trials, cardiovascular disease, breast cancer, osteoporotic fractures, dementia, risks and benefits, Clinical Trials Data Monitoring Committees, Estrogen Replacement Therapy, Feasibility Studies, Female, Great Britain, Human, Mass Media, Outcome Assessment (Health Care), Patient Selection, Postmenopause, Randomized Controlled Trials, methods, Research Design, Research Support, Support, Non-U.S. Gov't, Women's Health
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 12626209
Web of Science ID: 180347100002
URI: http://researchonline.lshtm.ac.uk/id/eprint/17679

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