Sero-epidemiological patterns of Epstein-Barr and herpes simplex (HSV-1 and HSV-2) viruses in England and Wales

Morris, MC; Edmunds, WJ; Hesketh, LM; Vyse, AJ; Miller, E; Morgan-Capner, P; Brown, DWG; (2002) Sero-epidemiological patterns of Epstein-Barr and herpes simplex (HSV-1 and HSV-2) viruses in England and Wales. Journal of medical virology, 67 (4). pp. 522-527. ISSN 0146-6615 DOI:

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The aim was to carry out a population-based seroprevalence survey of Epstein-Barr virus (EBV) across a wide age range in England and Wales and to identify any associations between EBV and herpes simplex virus types one and two (HSV-1 and 2). Sera from an age-stratified sample of 2,893 individuals, submitted for diagnostic purposes to 15 public health laboratories in England and Wales in 1994, were tested for immunoglobulin G (IgG) antibody to EBV. The samples had been tested previously for IgG antibody to HSV-1 and HSV-2. The serological profile of EBV was consistent with an endemic infection with peaks in transmission in those less than 5 years old and in young adults. An age adjusted analysis found a significant association between EBV and HSV-1 seropositivity that is most likely explained by similarities in their mode of transmission. The very low seroprevalence of HSV-2 in this sample complicated the comparisons of EBV and HSV-1 with HSV-2. Any associations were most likely explained by chance. Given the association between EBV and HSV-1, it is likely that recently documented epidemiological changes in HSV-1 also apply to EBV. Continuing surveillance of these herpesviruses is necessary as the predicted changes could have a significant public health impact, especially in the young adult population. (C) 2002 Wiley-Liss, Inc.

Item Type: Article
Keywords: seroprevalence, herpes viruses, association between viruses, Infections, pathogenesis, children, type-1, Adolescent, Adult, Age Distribution, Child, Child, Preschool, England, epidemiology, Enzyme-Linked Immunosorbent Assay, methods, Epstein-Barr Virus Infections, epidemiology, immunology, virology, Female, Herpes Genitalis, epidemiology, immunology, virology, Herpesvirus 1, Human, immunology, isolation & purification, Herpesvirus 2, Human, immunology, isolation & purification, Herpesvirus 4, Human, immunology, isolation & purification, Human, Immunoglobulin G, blood, Incidence, Infant, Logistic Models, Male, Sex Distribution, Wales, epidemiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 12115998
Web of Science ID: 176589900009


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