Risk of malaria attacks in Gambian children is greater away from malaria vector breeding sites


Clarke, SE; Bogh, C; Brown, RC; Walraven, GEL; Thomas, CJ; Lindsay, SW; (2002) Risk of malaria attacks in Gambian children is greater away from malaria vector breeding sites. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 (5). pp. 499-506. ISSN 0035-9203 DOI: 10.1016/S0035-9203(02)90419-0

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Abstract

The causes of local variation in the prevalence of malaria were investigated in rural Gambia. Cross-sectional prevalence surveys were carried out among 1184 young children (aged 6 months-5 years) in 48 villages, at the end of the transmission season in 1996. Villages were categorized according to distance from the nearest vector breeding sites, and the patterns of malaria transmission, infection and disease compared. Children living in villages within 3 km of breeding sites experienced more infective bites, and higher prevalences of parasitaemia and spleen enlargement than less-exposed children living further away. Clinical illness, in contrast, was more common among infected children who were less exposed. Infected children living 3 km or more from breeding sites were more likely to have high-density parasitaemia (odds ratio [OR] = 1.98), fever (OR = 2.60) and high-density parasitaemia together with fever (OR = 3.17). Clinical attacks did not decline in older children, as seen amongst children who were more exposed. These findings show that significant differences in the risk of infection and clinical attacks can occur over very short distances. The age at which protective immunity is acquired may be delayed in villages where transmission intensity is lower, thus increasing the risk of a clinical attack following infection. Communities with the lowest vector densities may be those at greatest risk of disease.

Item Type: Article
Keywords: malaria, Plasmodium falciparum, children, entomological, inoculation rate, clinical attack prevalence, The Gambia, Plasmodium-falciparum, west-africa, transmission intensity, bed-nets, morbidity, area, mortality, epidemiology, density, prevalence
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 12474476
Web of Science ID: 179609800009
URI: http://researchonline.lshtm.ac.uk/id/eprint/17612

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