Skin microbiota: a source of disease or defence?


Cogen, AL; Nizet, V; Gallo, RL; (2008) Skin microbiota: a source of disease or defence? The British journal of dermatology, 158 (3). pp. 442-55. ISSN 0007-0963 DOI: https://doi.org/10.1111/j.1365-2133.2008.08437.x

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Abstract

Microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. Advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. Current data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic. This review will summarize current information on bacterial skin flora including Staphylococcus, Corynebacterium, Propionibacterium, Streptococcus and Pseudomonas. Specifically, the review will discuss our current understanding of the cutaneous microbiota as well as shifting paradigms in the interpretation of the roles microbes play in skin health and disease.

Item Type: Article
Keywords: Corynebacterium diphtheriae/immunology, Female, Gram-Positive Bacterial Infections/immunology, Gram-Positive Cocci/growth & development/immunology, Humans, Male, Metagenome/*immunology/physiology, Microbial Viability/*immunology, Propionibacterium acnes/immunology, Skin/*microbiology, Corynebacterium diphtheriae, immunology, Female, Gram-Positive Bacterial Infections, immunology, Gram-Positive Cocci, growth & development, immunology, Humans, Male, Metagenome, immunology, physiology, Microbial Viability, immunology, Propionibacterium acnes, immunology, Skin, microbiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 18275522
Web of Science ID: 253120700003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1761

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