Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.


Park, JY; Dahm, CC; Keogh, RH; Mitrou, PN; Cairns, BJ; Greenwood, DC; Spencer, EA; Fentiman, IS; Shipley, MJ; Brunner, EJ; Cade, JE; Burley, VJ; Mishra, GD; Kuh, D; Stephen, AM; White, IR; Luben, RN; Mulligan, AA; Khaw, KT; Rodwell, SA; (2010) Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium. British journal of cancer, 103 (5). pp. 747-56. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6605802

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Abstract

BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent. METHODS: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ). RESULTS: Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >or=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results. CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 20648013
Web of Science ID: 281287700022
URI: http://researchonline.lshtm.ac.uk/id/eprint/176010

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