Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics

Partidos, CD; Steward, MW; (2002) Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics. Combinatorial chemistry & high throughput screening, 5 (1). pp. 15-27. ISSN 1386-2073 DOI: https://doi.org/10.2174/1386207023330589

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Antigen recognition by antibodies or ligand-receptor interactions involve small areas of the molecule named epitopes that are normally conformational in nature. The availability of combinatorial peptide libraries has provided a powerful tool for selecting novel sequences which mimic conformational epitopes (mimotopes) either structurally and/or immunologically. These mimotopes can be particularly useful in a number of situations, including: the development of vaccines against tumors, infectious diseases or allergic conditions; the design of molecules which can act as agonists or antagonists of various biologically-important molecules; and for the development of diagnostic assays. This article reviews the authors work on the application of combinatorial peptide libraries to identify mimotopes of protective B-cell epitopes from various pathogens, and the search for molecules able to block the biological activities of TNF-alpha, a cytokine which plays a key role in inflammation.

Item Type: Article
Keywords: Tumor-necrosis-factor, virus-induced encephalitis, random, peptide library, b-cell epitopes, synthetic peptide, measles-, virus, tnf receptor, antibody-response, fusion protein, t-cell, Amino Acid Sequence, Animal, Antigens, Viral, immunology, therapeutic use, Epitopes, immunology, therapeutic use, Human, Molecular Mimicry, immunology, Molecular Sequence Data, Parasitic Diseases, immunology, therapy, RNA Virus Infections, immunology, therapy, Vaccination, Vaccines, Synthetic, immunology, therapeutic use, Viral Vaccines, therapeutic use
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Vaccine Centre
PubMed ID: 11860336
Web of Science ID: 173968300003
URI: http://researchonline.lshtm.ac.uk/id/eprint/17577


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